noveltune Chapter 22 The Birth of a Miracle Drug
Chapter 22 The Birth of a Miracle Drug
I hurriedly climbed to the third floor and pushed open the door.
I saw Liu Yide busy at the lab bench.
Because the experiment was interrupted, Liu Yide frowned, and before he could speak, Alessandro, who was panting heavily, spoke up.
"Sir, I'm doomed."
Alessandro's expression was one of despair.
"What happened?"
Liu Yide glanced at him and put down the measuring cup in his hand.
"Lorenzo, he... he might not make it. His temperature has been consistently high, and he's already in shock. Federico said he's finished..."
When he said "It's over," Alessandro's shoulders slumped and his back bent. He was completely consumed by despair.
Looking at Alessandro's ashen face, Liu Yide recalled the smugness he felt a few days ago when he brought Lorenzo here.
Marquis's son!
A stepping stone into high society.
People...
He was so excited!
Or rather, how strong a yearning is for the future.
Actually, Liu Yide didn't have much ill will towards Alessandro; the guy was just like any other ordinary person.
It means doing everything in one's power to seize the opportunity.
Climbing upwards step by step.
This is what ordinary people are like—they always have to pay various prices to succeed.
"I warned you before, this treatment is effective, but it's also dangerous; it could kill someone. Why were you in such a hurry?"
Alexandro opened his mouth, looked at Liu Yide, and his expression became somewhat complicated.
"Sir, I... I really want to improve."
After saying that, his shoulders slumped completely.
He, who originally wanted to ask for help, seemed to already know the answer.
"Sir, I, you, you..."
Looking at Alessandro, whose face was ashen and whose expression was one of despair, Liu Yide weighed the options in his mind.
Isn't the question being weighed against what trouble Lorenzo's death will cause?
After all, in this day and age, which clinic doesn't have people dying?
The powerful and wealthy?
So what?
It would be normal for a king to die at the hands of a doctor.
Therefore, Lorenzo's death will not cause any trouble for the clinic or himself.
The only one in trouble is Alessandro.
Whether there's a reason or not, who would give this as a favor?
If you deliver it wrong, someone could die.
Even if you want to improve, this isn't the way to do it.
If you're not careful, you could end up in jail.
Liu Yide frowned and glanced at Alessandro.
Feeling the man's gaze, Alessandro, his face filled with despair, raised his head as if grasping at the last straw, and spoke in a pleading tone, clinging to the last glimmer of hope.
"Sir, yes, or else, please go down and take a look."
Liu Yide could have refused Alessandro's request, but seeing his desperate look, he couldn't bring himself to do it.
Liu Yide nodded and sighed.
"Alright, let's go take a look."
Ah, the ways of the world. There's no escaping them.
Bro, what's wrong?
cooked!
The moment Liu Yide entered the ward and looked at the patient, this thought immediately flashed through his mind.
Although the patient on the bed had wet towels draped over his forehead and chest, his whole body was still burning red, just like a cooked lobster.
Although Hyde and the others had high fevers when they were treated at the port, they hadn't gotten this bad.
"Sir, we have tried all the methods to lower the temperature, but nothing has worked."
"Where are the patient records?"
As soon as Liu Yide finished speaking, Luca hurriedly handed over the report, his expression extremely respectful.
This seemingly insignificant medical record finally came in handy at this moment.
Even if a doctor has never treated this patient.
But now, by simply picking up the medical record, one can clearly see the patient's temperature changes and the progression of their condition. This allows for more accurate and targeted treatment.
And this was Liu Yide's invention!
"My temperature was over 41 degrees Celsius last night..."
Liu Yide frowned. Was this stewed meat?
What should we do after such a long period of extremely high temperatures?
Without any hesitation, Liu Yide took out a paper package:
"Give him this medicine first."
"medicine?"
When Federico saw the paper package in Liu Yide's hand, he subconsciously connected it to his recent research.
"Sir, is this your research?"
"Yes, it should have some effect."
Liu Yide nodded.
Although Liu Yide noticed a common thread in the treated cases when he first reviewed the clinic’s medical reports—some patients experienced shock due to extremely high fever.
This is an inevitable consequence of treating syphilis with malaria—high fever!
However, a high fever can cause shock.
In this day and age, the only thing we can do when faced with a high fever is to use physical cooling methods. Quinine can treat malaria, but it can't directly reduce fever. Salicylic acid is somewhat useful, but its side effects are terrifying—it can cause vomiting and stomach ulcers.
The severe side effects meant that before the illness was cured, the person died from the effects of salicylic acid.
In that instant, a flash of inspiration struck Liu De—antipyretics… aspirin!
Aspirin, also known as acetic salicylic acid, has an incredibly simple synthetic route—salicylic acid reacts with acetic anhydride in a single step.
The raw materials are readily available, the technology is mature, and most importantly—this thing is a true "panacea".
It has antipyretic, analgesic, and anti-inflammatory properties, and it's a staple in almost every family's medicine cabinet in later generations.
More importantly, it can be used in the treatment of syphilis, and it has gained a reputation for treating syphilis.
It doesn't necessarily have to be truly useful, but it must be miraculous. As for whether it's effective or not—the patient survives because of it, and if they die... well, medicine heals those who are destined to be healed!
After determining his research direction, Liu Yide began his research in this area.
Salicylic acid is readily available.
Acetic anhydride, that's also available.
Ethanol is fine as a recrystallization solvent.
……
The problem is purity; I've been working on it for weeks, but I can't seem to improve it. But I can't worry about that now.
Alessandro, standing to the side, hurriedly said:
"Quickly, give him the medicine! The doctor's medicine will definitely work."
Soon, a glass of liquid mixed with aspirin was poured into the patient's mouth.
Alessandro watched as the medicine was poured into Lorenzo's mouth and exclaimed excitedly:
"Sir, you've taken the medicine. Will it... will it work?"
His voice trembled slightly with nervousness; after all, this was their last hope.
"Um……"
Liu Yide didn't answer him, but looked at the sheets soaked with sweat. This guy had been burning at such a high temperature for so long, how much sweat must he have produced!
Severe dehydration can also be fatal.
Immediately, some knowledge from those special years flashed through Liu Yide's mind—this situation required the infusion of saline/glucose to replenish water and electrolytes, and after the dehydration was corrected, the body temperature would drop significantly.
"Federer, I need something more."
Looking at the list, Federico was completely baffled.
"Syringe, glucose? Glass bottle? Rubber tubing..."
The list even includes pressure cookers.
"Is there anything wrong with this?"
Alessandro was also somewhat puzzled. He didn't know what the other party was going to do, but he simply didn't understand.
"I... I'm not quite sure either."
Although Federico was a doctor, he genuinely didn't know what these instruments were for.
However, Liu Yide quickly provided their answer.
"Replenish fluids!"
Hanging the bottle filled with glucose solution on the bed frame, Liu Yide said:
"High fever and shock are partly caused by severe dehydration. Intravenous fluid therapy can alleviate his condition to some extent..."
In fact, Liu Yide didn't understand the medical principles at all; it was all popular science content from those years.
Since the public account's science popularization article says that IV infusion is necessary, then let's get it done.
Because of the special circumstances of those years, even knowledge about preparing IV drips at home became popular.
However, no sooner had he finished speaking than Luca, standing beside him, suddenly seemed to have thought of something and said:
"No, sir, you can't do that!"
Alessandro asked in confusion:
"Dr. Luca, what's wrong?"
"Sir, you said that this method of intravenous infusion has been used for a long time, and it can indeed be effective to some extent. However, intravenous infusion treatment may also worsen the condition. Books have said that this is a very dangerous method, and even patients who did not originally have a fever may develop a fever as a result."
Federico then remembered that such a treatment did indeed exist. He explained:
"Sir, decades ago, during a cholera outbreak in England, doctors discovered that cholera patients lacked water and salt in their blood. They injected boiled saline solution into the patients' veins, and although some patients survived and recovered..."
However, this treatment method is very dangerous—although it can save lives, some people may experience a worsening of their condition or even die from sepsis during the treatment process!
Their intervention startled Liu Yide. Was it dangerous?
Looking at the latex tube in his hand, Liu Yide thought for a moment, then shook his head:
"It might be dangerous in someone else's hands, but that's them, not me. The worsening of your condition that you mentioned is actually caused by a secondary infection."
The problem likely stems from inadequate water treatment. The British typically use boiled water, while intravenous infusions should use distilled water, which, even if used, requires secondary treatment.
In addition, the bottles, syringes, and other equipment require high-temperature sterilization, which goes beyond simply boiling them in water. The best method is prolonged high-temperature sterilization in a pressure cooker. This knowledge was clearly lacking at the time, thus increasing the risk of secondary infections during intravenous infusions.
"Secondary infection? That's because the water wasn't properly treated."
Liu Yide stated bluntly:
"Using distilled water and autoclaving the equipment will solve the problem."
Thanks for all that miscellaneous knowledge!
We really need to be grateful. After all, although intravenous infusion was invented half a century ago, it wasn't until the 1920s that doctors and experts used sterilization methods to effectively remove pyrogens from the fluid and completely solve the problem of pyrogen reactions in intravenous infusion.
That's how intravenous infusion became widespread.
These seemingly insignificant techniques, such as disinfection, sterilization, and even the preparation of glucose and saline solutions, are precisely the result of centuries of research by generations of doctors.
Liu Yide is someone who stands on the shoulders of giants!
Even if you only have a slight understanding of it, that knowledge is timeless!
"That's right, others can't, but you definitely can!"
Federico had almost unconditional faith in the gentleman.
Soon, Liu Yide got busy.
Although the rubber tubing was readily available, the IV drip tube was made by Liu Yide from memory using rubber tubing and glass tubing.
The 5% glucose solution has been set up. Next, it will be administered via intravenous drip.
The dropper needle was modified from a syringe needle. One end of the glass tube was connected to the needle, and the other end was connected to a rubber tube. The needle tip was very thick, and when the needle tip was inserted into the vein... it failed.
This is normal; after all, intravenous injection is a technical skill.
After trying five or six times, blood finally returned to the glass tube.
At this moment, Liu Yide, covered in sweat, couldn't help but breathe a sigh of relief. He even sighed inwardly, wondering how so many people could perform surgery and cure diseases after transmigrating.
Even I get this nervous just to get a shot.
Then, the 5% glucose injection diluted with distilled water was injected into Lorenzo's body drop by drop.
The rest is quite simple: just wait.
Everyone stared at the thermometer.
Alessandro stood in the corner, gazing longingly at the little red figure on the bed.
Ten minutes. 41.5℃.
Twenty minutes. 41.0℃.
Although he had only retreated slightly, Federico's eyes widened, and his tone was somewhat uncertain.
"The fever... is really starting to go down."
He even looked at the thermometer against the light, wanting to confirm it again.
Forty minutes.
39.2 ° C.
The patient's breathing stabilized, and his complexion gradually changed from bright red to rosy.
For a moment, everyone was stunned:
"Sir, the fever has really gone down!"
Alessandro simply made the sign of the cross on his chest:
"Thank God, I'm saved..."
Federico's gaze toward Liu Yide was no longer simple admiration, but had turned into fanaticism!
"My God, sir, your medicine really works! This, this is simply a miracle!"
Federico exclaimed.
The last time he said this was at the port hospital, when he saw sailors recovering from syphilis.
But this time, he personally witnessed another miracle.
(This is a new book, and I'm facing some tough challenges. Please, all you big names, don't wait until it's finished to read it! I'm begging you to read it!)